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What began as a wound-healing observation has since evolved into one of the most studied tripeptides in dermatological research, with documented effects on collagen synthesis, matrix metalloproteinase regulation, and oxidative stress modulation

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That GPCRs exhibit constitutive activity in the absence of any agonist has been proposed to explain why certain ligands, originally thought to be antagonists, may act to inhibit basal activity of unoccupied receptors (i.e., they are inverse agonists) (Costa and Cotecchia, 2005)

Finding the balance requires attention to technique