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Weight loss typically becomes measurable within the first month and builds gradually as the dose increases over the following months, though the pace and total amount varies significantly from person to person

The dosage may be increased to 9 mg, 14.5 mg, or 17.2 mg after at least 30 days at each level based on treatment response and tolerability, according to the FDA

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They are intended as adjuncts to lifestyle modifications including reduced-calorie diet and increased physical activity, not as standalone treatments

In humans, it is located in chromosome 12 while in mouse it is found in chromosome 10