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In the SELECT trial that included over 17,000 patients with obesity and established CV disease, but without diabetes, weekly s.c

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GLP-1 Synthesis GLP-1 and GLP-2 were identified in the distal small intestinal mucosa as the product of post-translational processing by prohormone convertase 1/3 (PC1/3) of the proglucagon gene product (9) which in the Islets is processed by PC2 to yield glucagon (75, 87, 97)

Im also a realist who suspects that the final verdict on this medicine is many years away