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In empagliflozin-treated mice, renal growth was significantly attenuated, and molecular markers of renal growth were reduced in proportion to the reduction in hyperglycemia

Hydrobiologia 664:95105

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The reduced IGFBP binding also enhances tissue penetration and distribution, allowing IGF-1 LR3 to more effectively reach target tissues throughout the body after systemic administration

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Mintoff D, Agius R, Fava S, Pace NP