According to Molecular Metabolism [2], the receptor is predominantly expressed in pituitary somatotroph cells responsible for GH production and in hypothalamic regions such as the arcuate nucleus, which coordinates endocrine feedback loops and systemic energy metabolism
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As pharmacologic weight-loss therapies become increasingly common in clinical practice, awareness of uncommon causes of focal abdominal pain may help clinicians avoid misdiagnosis and unnecessary interventions in patients undergoing substantial weight loss
As part of the study, which was carried out by researchers at Case Western Reserve University School of Medicine and followed 83,825 patients with obesity for one year after they began taking semaglutide or other weight loss drugs as part of treatment
