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For example, reduced levels of SCFAs (like butyrate, which is normally made by good bacteria) can weaken the BBB, making the brain more vulnerable to harmful substances

(2021) used intra-articular injection and decide to replicate it

When insulin sensitivity decreases, the body needs to produce more insulin to achieve the same effect

For spinal structures with naturally limited blood supply (particularly the intervertebral discs, which are largely avascular), this enhanced circulation to surrounding tissues can make a meaningful difference in healing capacity

and R.P

MOTs-C may pose significant risk for immunogenicity for some routes of administration, the agency said in 2023