fda removes tirzepatide from shortage list The says the Zepbound is over. That's rattling the weight loss industry Eli Lilly's weight loss drugs

He explained: We believe at least one of the mechanisms for how these drugs reduce alcohol drinking is by reducing the rewarding effects of alcohol, such as those related to a neuro-transmitter in our brain, which is dopamine

it triggers glucose-dependent insulin release from the pancreas (meaning insulin goes up when blood sugar is high, not when it is already normal)

Doi: 10.1056/NEJMra1905136.

Bachhawat AK, Yadav S

Some interest has emerged in research circles around whether GLP-1-based therapies might influence body composition specifically the ratio of fat mass to lean mass during weight loss but this remains an area of early, exploratory investigation and should not be over-interpreted

Notably, tirzepatide is believed to activate the cAMP signaling pathway over beta-arrestin recruitment at the GLP-1 receptor