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however, repeated administration may cause tachyphylaxis due to depletion of endogenous norepinephrine stores

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The oxygen free radicals oxidize the lipid because the granulocytes and macrophages produce an excess amount of O 2 , H 2 O 2 during the phagocytosis

A separate study in the Journal of Orthopaedic Research reported consistent biomechanical and histological improvements in medial collateral ligament (MCL) repair over 90 days, across oral, topical, and intraperitoneal administration

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Day, MD, FACS