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(2006) 2:e116

Metabolically and clinically the most detrimental effects of IR are due to disruption in insulin-mediated control of glucose and lipid homeostasis in the primary insulin-responsive tissues: liver, skeletal muscle, and adipose tissue

For background, this means that a drug company "has taken exhaustive measures to get it approved, so they've done all this testing and paid all this money," Decotiis explains

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A rapid onset is also unusual, but the goiter may rarely grow from normal to several times the normal size in a few weeks

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