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Found in the small intestine, GLP-1 triggers the release of insulin, which is responsible for helping the human body convert food into energy

The ago-allosteric small molecule compound 2 enhances binding of the agonist GLP-1 but does not affect binding of the antagonist exendin (9-39) and it cannot be inhibited by the peptide antagonist exendin (9-39), which is not surprising considering the intracellular binding site of compound 2 32,35,36

Bonmatin J-M, Smith ICP, Jarrell HC, Siminovitch DJ (1990) Use of a comprehensive approach to molecular dynamics in ordered lipid systems: cholesterol reorientation in ordered lipid bilayers

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That is a substantial advance for a field where durable pharmacologic options have historically been limited