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These are neurotoxin induction-based models (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 6-hydroxydopamine (6-OHDA) and agricultural pesticides (rotenone, paraquat)), pharmacological models (reserpine or haloperidol treated rats), and genetic models (-synuclein, leucine-rich repeat kinase 2 (LRRK2), DJ-1, phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK-1) and Parkin)

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There has also been clinical development of an analog known as CB4211, which appears in federal clinical trial records

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What Science Says Last Updated: Nov 13, 2025

With GLP-1 therapy, a supportive diet and exercise regimen, and the insight from DEXA scans, you can lose weight confidently knowing youre preserving your strength and metabolism