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Recently, we observed that OTA induces liver damage preferentially to the cytochrome P450 (CYP)-expressing pericentral lobular zone, similar to hepatotoxic substances known to be metabolically toxified by CYP, such as acetaminophen or carbon tetrachloride

AMPK downstream effects are blunted in T2D patients, exacerbating hyperglycemia and hyperlipidemia (Fig

Conclusion: A Foundation for Longevity Age management is evolving beyond surface-level treatments toward approaches that address the underlying biology of aging

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JAK2, Janus kinase 2