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The same center also showed that in laboratory animals with DEN-induced HCC, liver tissue was characterized by low levels of apoptosis as indicated by a reduction relative to the control of DNA fragmentation and expression of genes such as p53, caspase 9 and 3, and an increase in IL-6 and TGF-1

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These favorable results require further clinical trials in order to elucidate whether these effects will result or not in reduced mortality

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