Endocrinology 158 , 12311251 (2017)
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brown or amber discolouration indicates oxidative degradation Visible particles : Particulate matter suggests microbial contamination or peptide precipitation Loss of vacuum : If the vial stopper is no longer under slight vacuum when punctured, sterility may be compromised Freeze-Thaw Stability Accidental freezing of reconstituted peptide does not necessarily render it inactive, but freeze-thaw cycles progressively reduce potency
What are common sources of contamination
PMID: 34234567 Davis, S., et al
Besides, an increasing number of studies show that epigenetic regulators play important roles in RA, like non-coding RNAs, DNA methylation, RNA methylation, and histone modifications (21)