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Essentially, its less aromatase, less estrogen, the brain turning the testosterone production signals back on, leading to a guy making his own testosterone again

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Also noted in Table 2 , several GLP-1 RAs have demonstrated favorable effects on secondary kidney outcomes

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Expert Perspective Across two decades of real-world data, combining metformin with GLP-1 RAs consistently seems safer than either agent alone, a finding that is reassuring to clinicians and supports informed routine clinical decision-making in the evolving gluco-metabolic therapeutic landscape

DOHERTY, MIKE, et al