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This is attributed to its poor absorption, limited bioaccessibility, and active efflux transport (Xiao et al
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Other Ingredients: Filtered Water, Vegetable Glycerin, Phosphoric Acid, Citric Acid, Malic Acid, Natural (and Artificial) Flavors, Sucralose, Acesulfame-K, Potassium Sorbate (Preservative), Sodium Benzoate (Preservative)
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The observation that patients with AD carrying two alleles of the APOE4 risk variant have approximately half the cerebrospinal fluid (CSF) melatonin levels compared to those with only one allele of this variant [75] could suggests that APOE4/4 carriers might particularly benefit from supplementing with exogenous melatonin
doi: 10.1016/S0002-8223(21)03293-4 18
