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115 Another significant intracellular source of ROS is the NOXs, especially in response to physiological stimuli, including growth factors, hormones and cytokines, and pathological impulse, such as bacterial and viral infections

Histologically, the melanocytes appear atypical but are confined to the epidermis, and there is no lateral spread of individual melanocytes as is seen in melanoma

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the absorbed fraction was strongly correlated with water solubility, and sweaty skin showed significantly higher bioavailability than dry skin