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Direct receptor expression in human coronary endothelial and smooth-muscle cells has been difficult to confirm using validated antibodies, raising the possibility that some vascular effects are mediated indirectly through circulating immune cells, hepatic signaling, or central-nervous-system pathways [14]

Also, do you have any idea whether using this once would have any negative effect, or is this something thats considered harmful if used continuously throughout pregnancy

Neurol Sci Neurophysiol 41(1):2333

These effects could potentially shield the brain from the damaging effect of the disorder, leading to better long-term outcomes for patients

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In particular, treatment with semaglutide achieved a dose-dependent reduction of 2543% in CRP values, significantly greater than with placebo [80]