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When insulin/GLP-1RA fixed-ratio combinations are compared with basal insulin, a superiority in reducing HbA1c is observed, with overall benefit also in weight neutrality or weight loss, reduced hypoglycemia risk, and reduced insulin-dose requirement [19, 25,26,27, 30, 31]

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Signs of mineralocorticoid under-replacement are a drop in blood pressure after standing up, weight loss, and dehydration (blood test: plasma renin level increased, hyponatraemia)

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