doi: 10.1210/jc.2010-0490 150 FalutzJPotvinDMamputuJCAssaadHZoltowskaMMichaudSEet al
The continual release of cell-free hemoglobin from hemolysis depletes hemopexin and haptoglobin, a consequence of which is the reduced bioavailability of nitric oxide (NO), and vascular endothelial dysfunction that underlies the chronic organ damage in SCD pathology
Fluid resuscitation was then started with 10 mL/kg*h of balanced crystalloid (Plasmalyte, Baxter, USA) and 10 mL/kg*h of colloid (Geloplasma, Fresenius Kabi, France) over a period of 20 min, to restore an optimal preload based on an arterial pulse pressure variation (PPV) 13%
I left feeling confident and ready to apply what I learned
At Perfect B, every protocol is medically supervised, starts with a consultation, and is tracked with follow-up check-ins
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