STEP UP found the same pattern at a higher dose: participants on 7.2 mg were more likely than those on 2.4 mg to reach reductions of at least 20% and at least 25%, but "more likely" describes odds across a group
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Conversely, surgical lesioning of the subdiaphragmatic vagus nerve, or administration of muscarinic receptor antagonists, prevents early phase GLP1 release in response to intestinal glucose (Balks et al., 1997), and both first and second phase GLP1 secretion in response to intestinal infusion of large volumes of fat (Anini et al., 2002)
PLoS One 9 , e86219 (2014)