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Furthermore, this approach enables the identification of previously unrecognized or population-specific adverse events through comparative analysis across subgroups, contributing to more comprehensive drug safety profiling

Hopkins ND, Cuthbertson DJ, Kemp GJ, Pugh C, Green DJ, Cable NT, et al

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Activation of GLP-1 receptors on vascular smooth muscle cells reduces the autoregulatory response in afferent arterioles and increases renal blood flow

The counter-argument is that mechanistic evidence is strong, multiple lines of clinical evidence converge, and the risk profile at microdose levels is favorable