By curbing oxidative stress and inflammatory responses, GLP-1 RAs can help protect kidney cells from damage, making these drugs particularly useful for diabetic patients with AKD
Side effects such as nausea, diarrhea, vomiting and constipation that are common early on may also drive people away
It works through one core pathway tied to appetite signalling, gastric emptying, insulin response, and metabolic regulation
The studies are small, but they suggest: More regular cycles Improved ovulation Better outcomes with IVF in some cases Importantly, the most recent data (2024) shows no increased risk of birth defects, miscarriage, or pregnancy complications with GLP-1 exposure
Not for long-term use
Glucagon-like peptide-1 protects against cardiac microvascular injury in diabetes via a cAMP/PKA/Rho-dependent mechanism