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This narrative review is the first to focus on natural compounds that have demonstrated IgE suppression and regulation across common allergic diseases

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Xia FH, Chen Z, Jin Z, Fu

Orally administered glutathione is primarily absorbed in the intestine, while circulating glutathione is cleared by the kidneys, which leads to its poor absorption from the gastrointestinal tract

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Conversely, at high concentrations under direct exposure conditions, its iron-chelating properties become predominant, leading to a functional iron deficiency that specifically impairs mitochondrial Fe-S cluster proteins, resulting in an energy metabolism crisis and cell cycle arrest