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Similarly, there were statistically significant differences in favour of semaglutide for percentages of patients with at least a 10%, 15%, and 20% reduction in the STEP 1 to 3 studies

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doi: 10.1590/1678-4324-75years-2021200772 109 PintoM.SoaresC.AndreaniT.FidalgoF.TavaresF

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This multi-receptor mechanism distinguishes retatrutide from earlier generations of incretin-based research compounds including GLP-1 mono-agonists such as semaglutide, and dual GIP/GLP-1 agonists such as tirzepatide by introducing glucagon receptor activation as an additional metabolic axis

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