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Tabata et al., 1999) are illustrative for the pertinence of the poorly resolved problem, illustrative for the diversity of the carriers (i.e., hyaluronate gel carrier (Wang and Aspengberg, 1996), alginate/heparinsacharose microspheres and films (Yu et al., 1998), cellulose gel (Thorn and Aspenberg, 1993), defective form of Pseudomonas exotoxin (Siegall et al., 1994), fibrin adhesive carrier (Walter et al., 1996), biodegredable hydrogen gelatin (Tabata et al., 1999), natural coral, and collagen (Sikiric et al., 2018), there is an inescapable diversity of the carriers and thereby, an evident diversity of the obtained beneficial effects, and disable conclusion

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In summary, oral administration of iron chelators (especially DFP) provides a non-invasive and promising dosing route for treating brain iron accumulation, but it requires prolonged treatment to achieve effective concentrations, close safety monitoring due to chronic treatment at relatively large dose, and its efficacy might be constrained by peripheral iron binding and the need for sufficient BBB penetration

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