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thus, they were hypothesised as a treatment for BED [19, 20]

Additional questions include how to mitigate lean muscle mass loss, which is important for joint stability, and whether adding glucose-dependent insulinotropic polypeptide or glucagon receptor activation could offer advantages over GLP-1 agonists on their own

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After weekly subcutaneous injection, EX was slowly released from the microspheres by diffusion and microsphere rupture and reached a stable plasma concentration about 6-8 weeks after treatment (114)