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According to a preclinical study of APG-115 in AML patients, APG-115 strongly inhibits proliferation and promotes apoptosis through activation of the p53/p21 pathway in wild-type p53-expressing AML cells and in vivo

However, studies on the hypothesized permeability change and the microbiota composition are yet to be performed (178)

The subcutaneous layer is thicker, making it nearly impossible to accidentally inject into muscle

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After calculating the FDR and FC values, DEGs with FDR 1 were selected

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