Around 2 to 3 months: symptoms often improve a lot if dose increases have been slow
doi:10.1016/j.molmed.2017.08.001 4 de Picciotto NE, Gano LB, Johnson LC, et al
Akt is also a profound inhibitor of apoptosis due to its ability to inactivate pro-apoptotic molecules, including caspase-9 and the Bcl-2 homology3 (BH3)-only protein Bcl-XL/Bcl-2-associated death promoter (Bad), and by triggering the activity of the transcription factor NF-B
Trials 19 , 217231 (1998)
This paper was published in Neural Regeneration Research (Vol 9, No 10, 2014)
30 total for multi dose formats, but those formats are not commercially available in the US currently ( although there was some breaking news we had on the Zepbound kwik-pens today )