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Studies have shown reductions in Hb A 1c and weight loss in this population

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Patients typically find they are happy and do not consider retreating within at least 2-3 years

Similarly 48 , reported that Y2-R internalization results in receptor desensitization accompanied by a G i -refractory state

COMT normally converts: Levodopa 3-O-methyldopa (3-OMD) Dopamine metabolism also increases Tolcapone blocks COMT Increases levodopa levels in blood Increases levodopa delivery to brain Prolongs levodopa duration of action Reduces wearing-off symptoms Reduces motor fluctuations Special Point: Tolcapone inhibits COMT both in peripheral tissues and in the CNS, unlike entacapone (mostly peripheral)