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4 Geniposide alleviates mitochondrial dysfunction During the progression of NAFLD, hepatic mitochondrial ribonucleic acid (mtRNA) is sensitive to oxidative stress and lacks histone protection, and excessive ROS attack respiratory chain complexes and mtDNA and damage the mitochondrial ultrastructure, leading to mitochondrial dysfunction, which in turn affects hepatic metabolism, forming a vicious cycle (Sanyal et al., 2001)

Biolayer interferometry (BLI) assays showed that Arg13Ala weakened WD40 binding to both wild-type and clientized Thr1273Glu S heptapeptides, although the affinity for the clientized S heptapeptide was still 2.8-fold higher (Table 1, Fig

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These findings could also suggest differences in PCa prognosis based on the ancestry of the respective populations

FIGURE 5 3.6 ST dampens pyroptosis induced by CIRI through suppressing the PI3K/AKT/NF-B pathway We utilized WB to validate the findings from the network pharmacology analysis

doi: 10.1101/gr.1239303