surmount-1 trial tirzepatide obesity without diabetes once weekly for the treatment of in people with type 2 (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 Shifts in body mass index

(2.2) If additional glycemic control is needed, increase the dosage to 1 mg once weekly after at least 4 weeks on the 0.5 mg dose

The 12-week rotation protocol Week 1: Right abdomen, upper quadrant (above navel, right side) Week 2: Left abdomen, upper quadrant (above navel, left side) Week 3: Right anterior thigh, upper portion Week 4: Right abdomen, lower quadrant (below navel, right side) Week 5: Left abdomen, lower quadrant (below navel, left side) Week 6: Left anterior thigh, upper portion Week 7: Right abdomen, lateral (right side, toward hip) Week 8: Left abdomen, lateral (left side, toward hip) Week 9: Right anterior thigh, lower portion Week 10: Right upper arm (if partner available) or right abdomen central Week 11: Left anterior thigh, lower portion Week 12: Left upper arm (if partner available) or left abdomen central After week 12, restart the cycle

1, 2024 from US Food & Drug Administration (FDA-a)

You should call your doctor if you experience: Palpitations lasting more than a few minutes or occurring frequently Chest pain, pressure, or discomfort Dizziness, fainting, or extreme fatigue Shortness of breath Irregular heartbeats that feel very fast or out of control Your doctor may check your heart health through tests such as an electrocardiogram (ECG), a Holter monitor, or blood tests to check electrolytes and thyroid function

Only catch is that your body cannot produce it so you need to get them from your diet or supplements

The visit is usually anywhere between 30-60 minutes long based on the patient's history and concerns/questions