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FIGURE 5 SOMATIC MUTATIONS IN KEAP1 OR NRF2 Missense mutations in the KEAP1 gene have been identified in several human cancers, particularly in solid tumors in the lung, gallbladder and liver (Padmanabhan et al., 2006

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Genetics : A family history of gout increases susceptibility

However, when dysregulated, these same pathways can exacerbate inflammation and metabolic dysfunction