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Mice pre-treated with IgG1 and then DA-GIP show significantly more c-Fos + cells in the AP compared to mice pre-treated with IgG1 and then vehicle (Extended Data Fig

Further, small changes in lipid parameters and DBP were noted over 12 months, with moderate improvements in SBP

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In clinical trials, participants taking semaglutide reported feeling significantly less desire to overeat, which led to more consistent and sustained weight loss