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Key oral pathobionts, including P.g , F.n , Streptococci spp , and H.p , translocate to the gastrointestinal tract where they disrupt microbial ecology, compromise barrier function, and trigger dysregulated immune responses

Relaxivity ( r i ) measures the increase of the water (longitudinal or transverse) relaxation rate when 1 mM of paramagnetic (superparamagnetic, in our case) substance is present

Mol Cell Biochem 481 , 14871499 (2026)

doi:10.1016/j.arcmed.2020.04.015 11

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(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field