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Where XO4 + microglial transcriptomes demonstrated dysregulated expression of genes associated with late onset AD (Grubman et al., 2021)

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Expressed predominantly in monocytes and macrophages, NLRP3 [nucleotide-binding oligomerization domain (NOD)-, leucine-rich repeat (LRR), and pyrin domain-containing protein 3] is an intracellular pattern-recognition receptor that is activated by damage-associated molecular patterns (DAMPs) (Swanson et al., 2019

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Genetic and phenotypic basis of autosomal dominant Parkinsons disease in a large multi-center cohort