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564 HO-1 and GPX4 were downregulated due to Nrf2 defects in astrocytes, leading to increased mitochondrial fragmentation, DNA oxidation, and lipid peroxidation in mouse astrocytes, 564 suggesting that Nrf2 deficiency promotes ferroptosis in astrocytes in AD mice

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They also repair past oxidative damage and reduce the accumulation of gene mutations that can contribute to premature aging and skin disorders

For PCA analysis, all metabolites were used following quantile-normalization in the Statistical Analysis module of MetaboAnalyst 4.0