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This assumption was verified in a follow-up study that activation of anti-viral responses by polyinosinic-polycytidylic acid attenuated APAP-induced hepatotoxicity through transcriptional down regulation of RXR and PXR and their downstream CYPs [34]

Written informed consent to participate in this study was provided by the participants' legal guardian/next of kin

Pharmacokinetics Eight-weeks-old male C57BL/6 mice ( n =3 per group) were injected with a single subcutaneous dose of P5 or Ex4 (100 g kg 1 ), and blood was collected 1, 2, 4, 8 and 24 h later

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Elysium combines them in the Wolverine Stack single pen

Similarly, ICV injection of Ex-4 increased c-fos expression in alpha-melanocyte stimulating hormone (alpha-MSH)-immunoreactive neurons in the ARC of mice (Dalvi et al., 2012)