Any intervention targeting hair must be evaluated over appropriate timeframes
The METAOD006 (OPTIONS) oral Phase 2b trial measured weight at 12 and 24 weeks
PPIs are more powerful and common, but H2 blockers can also affect vitamin B12 absorption

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Side effects are uncommon
Obese mice and rats treated with AOD9604 showed significant decreases in adipose tissue depot weights, reductions in adipocyte size observed histologically, and improvements in body composition measured by DEXA scanning or MRI