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Side effects and safety considerations Common and usually manageable effects The most frequently reported side effects involve the gastrointestinal tract, particularly nausea, diarrhea, constipation, reflux, and reduced appetite, and they tend to cluster around dose-escalation periods

Ramdass M, Sing QY, Milne D, et al

Yaghootkar H, Freathy RM

Early improvements in triglycerides often appear first, while LDL and HDL changes develop progressively as weight decreases and metabolic health improves

Changing From a Progestin-Only Method (progestin-only pill [POP], Implant, or Injection or a Progestin-Releasing Intrauterine System [IUS]): The woman may switch from the POP on any day

If you notice anything unusual, contact your pharmacist or healthcare provider for guidance