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They secrete large amounts of collagen and fibronectin, disrupt the basement membrane, and induce epithelial apoptosis, resulting in irreversible architectural distortion

CA Cancer J Clin 73:1748 Sioud M (2019) Phage display libraries: from binders to targeted drug delivery and human therapeutics

Por isso, a prescrio precisa ser personalizada, levando em conta as condies clnicas e objetivos de cada pessoa