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Off-Label Use Considerations While guidelines focus on approved uses, doctors sometimes prescribe medications off-label, meaning for conditions the FDA hasnt officially approved

References Bray GAPJ

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I see this as good news whether you like intermittent fasting or not because what it tells me is that those who dont enjoy it arent missing out on much, but those who do are probably enjoying a little boost on top of the fact they enjoy doing it in the first place

Muirhead R, Vaessen S, Greenwood R

1 Heres what the 40-week results showed: HbA1c reductions: Tirzepatide 5 mg: reduced HbA1c by 2.01 percentage points Tirzepatide 10 mg: reduced HbA1c by 2.24 percentage points Tirzepatide 15 mg: reduced HbA1c by 2.30 percentage points Weight loss: Tirzepatide 5 mg: 7.6 kg (8.5% of body weight) Tirzepatide 10 mg: 9.3 kg (approximately 10% of body weight) Tirzepatide 15 mg: 11.2 kg (13.1% of body weight) Achieving target HbA1c: 92% of participants on 15 mg achieved HbA1c below 7% 51% achieved HbA1c below 5.7% (normal, non-diabetic range) These results were significantly better than semaglutide 1 mg (the comparison drug in the trial), where 81% achieved HbA1c below 7% and participants lost an average of 6.2 kg