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Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome

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The two hormones share an origin and a release mechanism, then split completely at the receptor

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These research advancements are rapidly translating into tangible clinical tools, with commercial platforms from companies like pulseData and Google Health emerging for predicting kidney failure and monitoring patient health ( FIGURE 5 6 Translational biomarkers & diagnostic platforms (blood, urine, imaging) Metabolomic signatures face significant challenges due to confounding by extrinsic factors (diet, medications including SGLT2i/GLP-1RAs, comorbidities) and the predominance of cross-sectional studies with modest sample sizes, limiting causal inference and generalizability