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A: Tretinoin is primarily used to treat acne and reduce signs of aging by accelerating skin cell turnover

114 MontalbettiE.BiscrT.Ferrier-PagsC.HoulbrqueF.OrlandiI.ForcellaM.et al (2021)

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13 C NMR (126 MHz, CDCl 3 ) 172.40 (C), 170.08 (C), 135.34 (d, J = 3.0 Hz, CH 3), 133.80 (d, J = 10.0 Hz, CH 6), 130.75 (d, J = 12.5 Hz, CH 6), 118.18 (d, J = 86.1 Hz, C 3), 38.97 (CH 2 ), 36.89 (CH 2 ), 36.64 (CH 2 ), 27.82 (CH 2 ), 27.56 (d, J = 16.7 Hz, CH 2 ), 22.96 (d, J = 50.4 Hz, CH 2 ), 22.11 (d, J = 4.1 Hz, CH 2 )

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High activity of NNMT is also correlated with lower levels of glucose transporter 4 (GLUT4), which is vital for glucose uptake from the bloodstream into fat and muscle cells