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Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
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Berberine , a plant alkaloid that lowers blood glucose and cholesterol through AMPK and is often called natures metformin, has no clinical evidence for cognition or neuroprotection, only animal work
Moreover, HA-based multifunctional hydrogels endowed with photothermal, antioxidant, and nitric oxidereleasing capabilities have achieved synergistic antibacterial and regenerative outcomes in diabetic wound models, illustrating the engineering potential of hybrid HAGSH constructs
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