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To this regard, GSH may also have direct anti-SARS-CoV-2 potential: indeed a computational study indicates that the binding of spike protein to ACE2 is maximal when ACE2-sulfur groups are in the form of disulfides and impaired when fully reduced to thiols: hence a prooxidant environment with low levels of GSH would favor viruses cellular entry ( The deficiency of GSH in the alveolar fluid in ARDS patients was found to correlate with the increased ROS-mediated lung cell injury and inflammation (Pacht et al., 1991

- H tr iu tr bnh vy nn LIU GLUTATHIONE C THC S LM TRNG DA NH LI N Glutathione ch thc l cht chng oxy ha tt nht m chng ta tm kim

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These findings raise concerns with respect to use of L-C as a therapy or supplement in individuals with MetS