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A 2.6% reduction in hip bone mineral density and a 2.1% reduction at the lumbar spine in 52 weeks (Hansen et al., 2024), combined with up to 10.9% lean mass loss over 72 weeks (Look et al., 2025), means that patients on GLP-1 therapy need a comprehensive musculoskeletal protection plan from day one
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Among people eligible for treatment, 33.1% (95% CI, 31.4-34.8), 28.1% (95% CI, 26.4-29.8) and 26.2% (95% CI, 24.6-27.9) met the exclusion criteria for tirzepatide, liraglutide and semaglutide, respectively
Next, side effects
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While individual results may vary, the effects of Endolift can last for several years
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