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Compared to retinol, GHK-Cu Repairs without damaging the skin barrier It is gentler and better tolerated Supports healing instead of causing controlled injury While both these anti-aging solutions are effective, GHK-Cu may be a better and more comfortable option for people with sensitive skin or long-term use

6e), suggesting a disturbance in mitochondrial ATP generation

Pickarts original 1973 discovery was based on observing aged liver tissue behaving like younger tissue when exposed to GHK-Cu

Methods A structured literature search was conducted by the research team with the assistance of an academic librarian, with searches of six electronic databases (PubMed, Embase [Elsevier], CINAHL Complete [Ebscohost], SportDiscus [Ebscohost], BIOSIS Citation Index, and Web of Science Core Collection [Clarivate]) for studies related to BPC-157 published through March 2025

doi:10.1172/JCI116842