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For example, the rivastigmine patch (Exelon) SmPC specifies application to the upper or lower back, upper arm, or chest, while certain hormone replacement therapy patches have different site recommendations

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Off-label prescribing is legal when a licensed healthcare provider determines that a medication may be appropriate for a patient, but it can expand use beyond the exact population studied for the drugs original FDA approval

Manning NJ, Davies NP, Olpin SE, Carpenter KH, Smith MF, Pollitt RJ, Duncan SL, Larsson A, Carlsson B: Prenatal diagnosis of glutathione synthase deficiency

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