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Moreover, the solvent effect (solvatochromic shift) is expected to contribute to the observed blue sift in the emission spectra of transferred DAA-GSH-AuNCs in organic solvents

Overall, redox signaling involving mtROS, the PRX3SRX axis, HIF-1, NRF2, and the NOXNADPH system constitutes a regulatory network through which mitochondrial dysfunction is communicated to the ER, nucleus, lysosomes, and peroxisomes, thereby amplifying organellar stress and shaping cell fate in AP ( Once calcium overload and oxidative stress have injured mitochondria, the next major determinant of outcome is whether those organelles can be removed through effective lysosomal-autophagic quality control

In parallel, an overview of hepatic oxidative stress, inflammation, and steatosis underlying DILI is provided, followed by extensive review and discussion of the pathophysiology of AD- and AP-induced DILI revealed in case reports, and animal and in vitro studies

10.1021/acsnano.3c10674 [DOI] [PMC free article] [PubMed] [Google Scholar] Zhang H., Forman H

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